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Meanwhile, AOD-9604's mechanism skips insulin pathways entirely, acting directly on adipocyte receptors to trigger lipolysis without the glucose side effects that make full-length growth hormone problematic for metabolic research

NNMTi treatment combined with lean diet substitution accelerated improved body weight fat loss, increased whole-body lean mass to body weight ratio, reduced liver epididymal white adipose tissue weights, decreased liver adiposity, improved hepatic steatosis, relative to a lean diet substitution alone