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This transformation enhances the responsiveness of immune cells to vitamin D, particularly by promoting antimicrobial activities in macrophages and modulating the development of dendritic cells that present antigens, which in turn influences T cell function [135]

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Prior to the roll-out of vaccines, the expansion of SARS-CoV-2-specific T cells and an interferon response were detectable in the blood even in the week preceding PCR positivity in asymptomatic and mild cases of primary SARS-CoV-2 infection [66]

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[Doctoral Thesis, Maastricht University]

Its safety profile across roughly 900 participants remains one of the strongest in this peptide category