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Additionally, the vagus nerve serves as a direct communication route between the gut and brain, transmitting microbial and immune signals from the gastrointestinal tract to brain centers involved in mood regulation

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18 and Extended Data Figs

Retatrutide titration protocol Retatrutide follows a similar monthly escalation pattern, but with different starting points and targets: Weeks 1-4: 1mg once weekly (initiation) Weeks 5-8: 2mg once weekly Weeks 9-12: 4mg once weekly Weeks 13-16: 8mg once weekly Week 17+: 12mg once weekly (maintenance) The retatrutide starting dose is lower at 1mg, reflecting the triple agonist mechanism and the need for careful GI adjustment