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Sato, T., Shimizu, T., Fujita, H., Imai, Y., Drucker, D

The New England Journal of Medicine, 389 (10), 877888

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Pharmacokinetics of tirzepatide demonstrated dose proportionality over the wide dose range, with C max of 180 nM in individuals treated with one dose of 8 mg and a C max of 260 nM with 15 mg/week dose in the clinical study, exceeding the EC50 values for GIPR and GLP-1R activations by approximately 10,000-fold and 250-fold, respectively (63)