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The AAFP recommends injectable therapy when rapid improvement is needed for severe deficiency or serious neurologic involvement

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What Does the Preclinical Research Show

Vitamin B12 is a water-soluble vitamin, meaning any remaining amount that your body cant use leaves your body through your urine

8 This effect increased with duration of therapy, and patients had an unclear prophylactic supplementation response

Semaglutide, Tirzepatide, and Retatrutide all fall into this category, though each generation adds more receptor targets