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No evidence supports cycling versus continuous use, and no studies have determined optimal treatment duration

While it does not treat active acne, it supports skin clarity by improving overall skin appearance

A 2026 biopharmaceutical review in a journal I do not trust said there is no identified high-affinity receptor, no validated molecular target, and a wide disconnect between the tidy preclinical effects and any coherent pharmacology

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Low dose oral micronized progesterone maintains a steady state of progesterone in the body, which reduces fluctuations and increased allopregnenolone production

References Akbarzadeh A, Rezaei-Sadabady R, Davaran S, et al