Some compounded GLP-1 products are mixed with other substances the FDA has called unsafe
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Here's what SURMOUNT-5 found in 751 adults with obesity (without type 2 diabetes) over 72 weeks: Tirzepatide group: Average weight loss of 20.2% Semaglutide group: Average weight loss of 13.7% That's a meaningful difference roughly 6.5 percentage points
A newer GLP-1 receptor agonist, tirzepatide, demonstrates weight loss as high as 20% change in body weight compared with 3% in the placebo group in a RCT
Using them can lead to failed tests and suspensions
So, if you stay on medication for weight maintenance afterwards, slower titration may add 6-12 months of payments to your total treatment cost