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Take a careful history about how long the patch has been present and whether it has changed in size, shape, colour or surface

In people with type 2 diabetes or specific cardiovascular risk factors, these can include improvements in insulin sensitivity, reduction in inflammatory markers, favourable effects on lipid profiles (particularly triglycerides), and potential cardiovascular benefits

Physical Examination A physical exam can give important clues

Moreover, interstitial glucose levels in the VMH and LH vary with blood glucose concentration [67], and these changes in glucose have been postulated to trigger meal initiation

Its often a reflection of something deeper, metabolic resistance, hormonal imbalance, or a system that hasnt been fully understood

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