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Collagen synthesis in adult skin is slow, elastin almost does not regenerate at all, and as the underlying volume drops, the dermis loses its scaffold and laxity becomes obvious at the jawline, temples, and under-eye region

Sprue, Fish tapeworm infestation or Blind loop syndrome (change in the course of the intestines after stomach surgery)

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According to the SmPC, these are classified as 'common' (affecting up to 1 in 10 people) and typically present as: [1] [2] Erythema (redness) Pruritus (itching) Swelling or induration Mild pain or tenderness Bruising These reactions are generally mild, self-limiting, and resolve within a few days without specific intervention