Some insurance companies experienced their worst financial performance on record after adding coverage of GLP-1s for weight loss
Its important for patients to understand that GLP-1 medications are not a skinny shot, but a tool designed to support metabolic health through long-term weight management
While GLP-1 receptor agonists (such as semaglutide and liraglutide) have demonstrated significant benefits in diabetes management, weight reduction, and cardiovascular outcomes in clinical trials, enhancing physiological GLP-1 through dietary and lifestyle modifications represents a foundational approach
Pharmacotherapy The use of currently available drugs is mainly based on their effectiveness in treatment of other hypoglycemic conditions such as insulinoma
Efficacy and Safety of Once-Weekly Semaglutide Versus Once-Daily Sitagliptin as an Add-on to Metformin, Thiazolidinediones, or Both, in Patients With Type 2 Diabetes (SUSTAIN 2): A 56-Week, Double-Blind, Phase 3a, Randomised Trial
Interestingly, exendin-4 is similar in structure and function to GLP-1, but is resistant to degradation by DPP4, allowing exendin-4 to remain in circulation for hours rather than just a few minutes
