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View Study [4]"Inhibition of activin-like kinase 4/5 attenuates cancer cachexia associated muscle wasting" Levolger S, Wiemer EAC, et al., 2019 Finding: LR3 IGF-I treatment effectively limited muscle mass loss in a cancer cachexia model, demonstrating its potent anti-catabolic effects and ability to preserve muscle tissue under conditions that normally cause severe muscle wasting
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A plateau doesn't mean failure
Moreover, GSTM2 overexpression reversed methionine choline-deficient diet (MCDD)-induced steatosis
However, if you have been at maximum dose for 12 or more weeks without adequate response, or if side effects prevent further dose increases, switching to tirzepatide is a reasonable next step
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