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These mechanisms regulate protein import, metabolic signaling, dynamics, and lipid synthesis, collectively sustaining mitochondrial homeostasis [68, 69]

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Diagnosis The diagnosis can be made on a clinical basis in many cases but, unless a long history of stable appearance is available, biopsy should be undertaken to rule out postinflammatory hyperpigmentation, pigmented intraepithelial neoplasia, dysplastic nevus, lentigo maligna, lentigo maligna melanoma, and superficial spreading melanoma.

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