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When antioxidant levels are insufficient to keep the free radicals in check, the free radicals start to damage proteins, lipids, and DNA, triggering various illnesses and health conditions, including the following: Lung diseases: Oxidative stress, such as that caused by smoking tobacco products, is related to a number of lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), acute lung injury (ALI), pulmonary fibrosis, and lung cancer

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SIRT1 expression was reduced in the frontal and temporal lobes of PD patients with dementia (Bose and Beal 2016)

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One study found that subjects consuming higher levels of tryptophan had significantly less irritability and depression and decreased anxiety than when they consumed lower levels

Specific effects depend on dose, format, individual factors, and concurrent interventions