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Ophthalmology is a particularly stark example: ranibizumab (Lucentis) had a biosimilar finally approved in the US only in 2022, years after European approval, and bevacizumab has been used off-label in ophthalmology for decades, depressing the economic case for on-label biosimilar investment

(c) Linagliptin, PDB ID 2rgu (Eckhardt et al., 2007)

New Guidance Reflects a Change in Thinking Recent national guidance from several medical societies now recommends a more tailored approach

Chang, Y., Hsieh, M.-H., Ju, P.-C

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Watchdog updates warnings for Ozempic-style drugs over potential risk of suicidal thoughts Mon 1 Dec 2025 at 4:58pm , updated Mon 1 Dec 2025 at 7:51pm In short: The Therapeutic Goods Administration has released a new safety alert for glucagon-like peptide-1 medications