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(2) Initially regarded only for its potential as a sleep-including factor, DSIP was soon suggested to induce other potential actions, such as mitigating pain, sleep cycle regulation, and mitigating withdrawal

Risk of bias assessment The results of evaluating the quality of the included studies are presented in online Supplementary Fig

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[3] Oxidative stress reduction Oxidative stress markers, including measured reactive oxygen species and lipid peroxidation products, fall by 35% with LipoEdge Glutathione supplementation, reflecting the direct intracellular antioxidant activity made possible by efficient cytosolic delivery