PMCID: PMC6785772
The overexpression of ACSL4 promotes the catalysis of various PUFAs, alters the cellular lipid composition, and ultimately increases the susceptibility of cells to ferroptosis (Cui et al., 2021)
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When incorporated into scaffold matrices and hydrogel formulations, thymosin beta-4 has been shown to support endothelial and epicardial cell proliferation, enhance blood vessel formation, and promote myocardial tissue repair in post-ischemic models