Weve had our time in the spotlight
Many factors deplete NAD+ levels in the body, including extensive free radical-induced DNA damage, chronic inflammation and immune activation, aging-related increase in consumption, and decrease in synthesis
The side effect comparison between the medications helps set expectations
Conversely, animal studies have also shown that brief courses of rapamycin can bolster health and longevity without the full spectrum of adverse effects seen with chronic dosing
Additionally, individuals may experience improved digestive function, as Vitamin B12 injections can enhance metabolic rates, thereby supporting weight loss initiatives
The direct relationship between tryptophan levels and depressive symptoms and fatigue has been demonstrated by Trp depletion experiments, as reviewed elsewhere [76], and is also of interest in the context of long-term COVID, as recent studies have shown a significant decrease in plasma Trp levels in PASC patients [48], and alterations in kynurenine pathway metabolites have been associated with cognitive impairment in long COVID patients [27], as well as with anxiety and depressive symptoms in COVID-19 survivors 6 months post-infection [66]
