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Through multi-target mechanisms, these active metabolites either directly activate the -catalytic subunit of AMPK (via phosphorylation at Thr172) or indirectly modulate upstream kinases (such as LKB1 and CaMKK ), thereby influencing the expression and activity of downstream key effector molecules, including ACC, SREBP-1c, and PPAR
Recombinant Vaccinia Viruses and Gene Gun Vectors Expressing the Large Subunit of Schistosoma Mansoni Calpain Used in a Murine Immunization-Challenge Model
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USA 115 , E2811E2818 (2018)
The pathway is not a free pass: transport is concentration-dependent, molecule-size-limited, and mucociliary clearance competes with absorption
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