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Comparative GHRH analogue pharmacology With DAC versus Without DAC Studies systematically comparing CJC-1295 Without DAC and CJC-1295 With DAC characterise the consequences of pharmacokinetic profile on GH secretion pattern the transient pulsatile GH release produced by Mod-GRF 1-29 versus the sustained tonic GH elevation produced by the long-acting DAC variant

10.1016/j.phrs.2013.11.002 72 SarkarS.CarrollB.BuganimY.MaetzelD.NgA

However, we mitigated the potential confounding effect of CAD through the use of MR analysis and by rigorously selecting genetic instruments that were strongly associated with GLP-1RAs, while excluding SNPs associated with CAD and other pleiotropic pathways

B/C, betaine/choline ratio