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The BRD4 binding motif, VHL E3 ligase binding motif, D-(+)-biotin motif, and linker are colored red, blue, purple, and black, respectively

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ROS can directly stimulate NLRP3 inflammasomes, thereby enhancing the secretion of IL-1 and IL-18 [308]

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How MSCs May Influence Autism Biology In preclinical models, MSC therapy has been associated with: Reduced neuroinflammation Decreased microglial activation Increased production of neurotrophic factors Enhanced synaptic plasticity Improved neuronal survival In mouse models of autism, MSC treatment has been linked to improvements in social interaction and reductions in repetitive behaviors