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Acting as a central node within the EFGR/PI3K/AKT/mTOR signaling axis, AKT1 dysregulation has been linked to different pathological conditions such as cancer, neurological diseases and diabetes (Hers et al., 2011) and it is recognized as an oncogene in melanoma (Wei et al., 2019)

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In parallel, HC induced the downregulation of RRM2B, a protein involved in mitochondrial DNA synthesis (Pontarin et al., 2012)