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Only 16% cite ineffectiveness as a reason, suggesting most believe the medications are effective

In humans, there are low amounts of DRD3 receptors found in the cortical regions

Survey data demonstrate people taking GLP-1RAs semaglutide and tirzepatide report reduced sedative and stimulative effects of alcohol 18

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J Ethnopharmacol 105(12):306311 Kasali FM, Irenge CA, Hamuli PM et al (2021) Ethnopharmacological survey on treatment of hypertension by traditional healers in Bukavu city, DR Congo

Alprostadil erections can occur without sexual arousal too (since its a local drug), and there is a risk of priapism or significant penile pain/burning