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Three eukaryotic SODs have been characterized based on their biochemical and molecular properties: the cytosolic copper-zinc (CuZn) dimeric form (known as SOD1), the mitochondrial tetrameric manganese (Mn) form (known as SOD2), and the extracellular tetrameric CuZn form (known as SOD3)

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The clinical outcome of targeting APLN/APLNR pathway for cancer therapy depends on the tumor type