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While many of these molecules showed promising results in preclinical rodent, minipig, or non-human primate (NHP) models, they could not achieve sufficient therapeutic windows to observe clinical weight loss without adverse events such as cardiac activation ( MK-0493 MK-0493 is an orally available small molecule developed by Merck ( Figure 2 )

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El Osta, R., Grandpre, N., Monnin, N., Hubert, J

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