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PHO2-dependent degradation of PHO1 modulates phosphate homeostasis in Arabidopsis

Petukhova L, Duvic M, Hordinsky M, Norris D, Price V, Shimomura Y, Kim H, Singh P, Lee A, Chen WV, Meyer KC, Paus R, Jahoda CAB, Amos CI, Gregersen PK, Christiano AM

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Potential identities were then added to an inhouse structure library including.mol files from Chemspider (Royal Society of Chemistry, London, United Kingdom) and then targeted on the initial raw data according to the following parameters: a 5 ppm mass tolerance, a 2 mDa mass tolerance for predicted structure fragments, a 5% CCS deviation, and multiple adducts (+H, + Na, +K, + Li, +NH4) within 5 ppm and 0.1 minutes

It may help reduce skin pigmentation by inhibiting the activity of the enzyme tyrosinase, which plays a role in melanin production