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Commercial Development: In August 2025, Jocasta Neuroscience raised $35 million in Series A funding to advance JN-0413, a proprietary -klotho formulation, through Phase 1 trials with IND submission planned for Q4 2026

Their individual mechanisms are reasonably well-characterized in preclinical literature, even though human trial data remain sparse for both

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Kch thch sn sinh Glutathione ni sinh C th chng ta c kh nng t tng hp Glutathione, v L-Cystine chnh l nguyn liu u vo quan trng nht (yu t gii hn tc )

Eur J Neurosci 25 : 25912603

It acts as a ceRNA or sponge for miR-1184, which interacts with the 3'UTR of the IGFBP-2 mRNA, inhibiting its expression and resulting in decreased cell migration, invasion and growth