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E.HuaD.KipnisJ.et al (2008)

High-dose methionine (above 100 mg per injection) can elevate homocysteine levels in susceptible individuals, increasing cardiovascular risk if used long-term without folate co-supplementation

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In contrast, at least 1 of the folate receptors, FR-, is expressed in hematopoietic cells and the kidney proximal tubules, among other tissues (Table 2)

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However, suitability depends on the overall nutrient composition and should be evaluated by a physician