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The study also reported upregulated gene expression of MMP1 and MMP2, which facilitate the removal of damaged collagen, enabling the formation of new, healthy fibers

doi: 10.4081/monaldi.2008.380 18 DowdSKRodgersGCCallenJP

Current research extrapolations suggest 1216 week treatment cycles followed by 48 week rest periods, though this is based on precautionary principle rather than evidence of receptor desensitization or tolerance development

If blood work is also being drawn, following any fasting instructions from your healthcare provider takes priority over these recommendations

Appl Microbiol Biotechnol 105 , 91039111 (2021)