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No increase in heart attacks or serious cardiovascular events was reported

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1 Despite the availability of multiple treatments, a substantial proportion of patients either fail to achieve remission, particularly in cases of treatment-resistant depression (TRD) and late-life depression

The review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines [15], with registration in NIHR-PROSPERO (CRD 42024505263)

Methods: A comprehensive synthesis of preclinical and clinical studies was conducted, focusing on the cellular mechanisms and systemic outcomes of GLP-1RA therapy in various models of sepsis and critical illness

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