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Richelsen, B

A, composed of 3943 amino acids, is cleaved from amyloid precursor protein (APP) (32)

Moreover, FOXO4-DRI was used to selectively induce apoptosis of senescent fibroblasts in both keloid fibroblast and organ culture senescent models, showing potential as a treatment that targets the senescence and apoptosis resistance observed in keloid fibroblasts

Semaglutide increases insulin secretion and improves glucose handling through GLP-1 receptor activation

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In aged mice, FOXO4-DRI treatment restored fur density, improved renal function, and increased physical activity levels, demonstrating functional rejuvenation through targeted senescent cell clearance