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J Biol Chem (2006) 281(45):3412434

Doses greatly exceeding the nutritional requirements (for example, hundreds of milligrams daily) have not been studied in randomized trials for safety, so one should avoid mega doses in pregnancy unless treating a specific condition (such as pyridoxine-responsive seizures) under careful supervision

120 The combination of enhanced insulin release with a reduction in food intake makes GLP-1 an attractive potential treatment for patients with type II diabetes

They require refrigeration and degrade over time

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doi: 10.1016/j.phrs.2021.105856