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The transcriptional regulation of DNL is mainly orchestrated by two key transcription factors: sterol regulatory element-binding protein 1c (SREBP1c), which is activated by insulin and liver X receptor , and carbohydrate regulatory element-binding protein (ChREBP), which is activated by carbohydrates [41,42,43] (Fig

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Strategies to improve NADs performance Because of these challenges, accurately delivering drugs to target tissues and improving patient quality of life have become the core objectives for NADs development and research