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Indias seasons bring distinct skin concerns: summer accumulates tan and pigmentation, monsoon brings congestion and fungal-related dullness, winter brings dehydration and surface roughness

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For example, C16-carnitine (10 M) may impair mitochondrial function in rat ventricular myocytes by accelerating ROS production and increasing the probability of mitochondrial permeability transition pore (mPTP) opening, whereas low concentrations (1 and 5 M) of C16-carnitine lightly hyperpolarize the m but do not open the mPTP [293]

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The alteration of the microbiome is observed in these patients (118, 119)

& Dilmaghani, S