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Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes Huang Y, He Y, Makarcyzk MJ, Lin H Frontiers in Bioengineering and Biotechnology (2021) This study demonstrated that FOXO4-DRI selectively removes senescent cells from human chondrocyte cultures expanded in vitro, providing direct evidence of the peptide's senolytic activity in human cells relevant to joint and cartilage aging
Jeschke MG, Klein D, Herndon DN
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JAMA Internal Medicine (2016): In over 1.5 million patients, incretin-based drugs, including GLP-1s, had an adjusted hazard ratio of 1.04 (95% CI, 0.811.35) for acute pancreatitis
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