Their combined application in murine NASH models and cultured fibrotic hepatocytes resulted in the attenuation of both fibrosis and steatohepatitis, successfully harnessing the benefits of both therapeutic modalities (Ha et al., 2023)
Zeng X, Xie YJ, Liu YT, Long SL, Mo ZC
In a recently published review, the advantages of eryptosis over hemolysis as a toxicological endpoint have been summarized, emphasizing that eryptosis in vitro testing has a higher sensitivity, is more accurate and reproducible, provides better quality control, and can shed light on the cytotoxicity-mediating molecular mechanisms compared with hemolysis [450]
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Plates were incubated at 37C for 2 h and then fluorescence was measured with excitation at 360 nm and emission at 460 nm using a ClarioStar Monochromator Microplate Reader (BMG LABTECH, Ortenberg, Germany)
Anti-inflammantory and antioxidant effects of vitamin A (212, 213), C (214, 215), D (216, 217) and E (213) also involve inhibition of NF-kB as well as activation of Nrf-2 signaling pathways involved in cellular antioxidant response (218, 219)
