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The same applied for PBMC mitochondrial functionality and metabolic activity as assessed by ex vivo approaches, whereas non-mitochondrial respiration rate was significantly affected by L-carnitine supplementation over time

Peer review Peer review information Nature Chemical Biology thanks Rudi Fasan and the other, anonymous reviewer(s) for their contribution to the peer review of this work

Higher tirzepatide concentrations mean smaller injection volumes for the same dose

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Newer data, including the 2025 SEMALEAN study, shows that lean mass can be largely preserved when adequate protein, resistance training, and body composition monitoring are built into the protocol

For low-risk situations where harms would be easy to detect, a trial with observation is reasonable