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Longitudinal changes in physical capacity from adolescence to middle age in men and women

Laboratory studies in renal function demonstrate that FOXO4-DRI administration restores kidney function in both accelerated aging models and naturally aged mice, indicating that senescent cell elimination can reverse organ-specific age-related deterioration

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CD8 + cytotoxic T lymphocytes mediate direct thyrocyte lysis via perforin, granzymes, and proteoglycans, and are recruited and activated by autoreactive CD4 + T cells through IL-12 and IFN- signaling