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676 The oncogene c-Myc directly upregulates a suite of glycolytic genes (HK2, PFK1, TPI, GAPDH, ENO, LDHA, and MCT1), intensifies glycolytic flux in cancer cells, 663,677,678 and stabilizes HIF-1 under normoxic conditions by inhibiting its proteasomal degradation through interaction with the von HippelLindau protein
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It means maintenance is becoming a real treatment phase, not an afterthought
[DOI] [PMC free article] [PubMed] [Google Scholar] 75.Wong WS, McLean AE
There was also a reduced risk of moderate exacerbation [6]
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