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Combined activation of GLP-1, GIP, and GCG systems theoretically provides complementary mechanisms: GLP-1-mediated insulin sensitization and satiety promotion, GIP-mediated enhancement of insulin secretion and adipose lipid buffering, and glucagon-mediated direct hepatic lipid oxidation and energy expenditure augmentation

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If lots of people start microdosing, it could re-trigger a GLP-1 shortage and make it harder for people with diabetes to access the medication

Even with approval, the FDA has instructed Eli Lilly to study the heart, liver, and other potential risks associated with this new pill