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When Tac enters an enterocyte of the intestinal mucosa as a highly lipophilic substance, it either migrates to the basolateral side and into the blood or is eliminated by CYP3A enzymes and P-gp
It can be considered as a storage form of estrogen that can be converted by HSD17B1 (17-Hydroxysteroid dehydrogenase) into estradiol
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The resulting complexes retain FcRn binding, suggesting the potential for favorable pharmacokinetics, while naturally occluding FcR interactions, eliminating the need for additional Fc silencing mutations
Temperature fluctuations
Samples (1 l) were loaded onto a Zorbax 300SB C-18 Nano-HPLC Chip (150 mm75 m, Agilent) with 0.1%(v/v) formic acid (0.6 l/min), and compounds eluted by an increasing 0.1%(v/v) formic acid, acetonitrile gradient (90%(v/v) final)
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