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The clinical significance of this effect is not fully characterized, but some providers recommend that women on oral contraceptives switch to a non-oral method (patch, ring, IUD, implant) when starting GLP-1 therapy, or use backup contraception during the titration period

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Int J Soc Sci Stud

Oral semaglutide 3, 7, and 14 mg doses were well tolerated over 52 weeks, with similar overall rates of adverse events as dulaglutide 0.75 mg, the most frequent being mild gastrointestinal events

Warning signs include decreased urination or very dark urine

[19] Spellman CW