doi: 10.3389/fphar.2022.963160 65 YiXGuoWShiQYangYZhangWChenXet al
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Per the FY 2026 ICD-10-CM Guidelines, when the encounter is for anemia management associated with the malignancy, and only the anemia is treated, the malignancy code is sequenced first, followed by D63.0
Bourgonje, M.S
Epidemiology: High levels of vitamin B12 were found in: Causes: Excessive supplementation (a direct increase in plasma vitamin B12 by excess intake or administration) Increased release of vitamin B12 from tissue stores (liberation from an internal reservoir): Solid tumors (especially hepatic or hematologic malignancies) Liver metastases Increased binding proteins: 7 Excess production: Liver disease (e.g., hepatitis, cirrhosis, hepatocellular carcinoma) damaged hepatocytes release haptocorrin (transcobalamin I) and B12 into circulation Myeloproliferative disorders these increase granulocyte production, which leads to more haptocorrin (transcobalamin I/III), a B12-binding protein produced by proliferating myeloid cells
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