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This effect may diminish over time with continued use and requires caution in patients with severe gastrointestinal disease or gastroparesis

Not everyone, however, has a great response to GLP-1 drugs and they can cause unpleasant side effects, like nausea, constipation and diarrhoea

In animal models of psychosis, liraglutide administration consistently led to a reduction of psychotic-like behavior 119,120,121 , which was also associated with increased brain-derived neurotrophic factor, CREB/p-CREB, and Trk-B expression in the hippocampus and prefrontal cortex 120 , and reduced serum and hippocampal tumor necrosis factor and oxidative stress 121

These effects are usually transient and can be minimised by eating slowly, avoiding large portions, and limiting high-fat foods

Women in the STEP trials lost a higher percentage of body weight than men on identical semaglutide doses

Fras JP, Davies MJ, Rosenstock J, Prez Manghi FC, Fernndez Land L, Bergman BK, et al