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The authors assessed the effect of formononetin on preventing mast cell degranulation in rat basophilic leukemia RBL-2H3 and human basophilic chronic myelogenous leukemia KU812 cells and saw reduced degranulation without any evident cytotoxicity [121]

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If symptoms remain bothersome after 10 weeks, a temporary dose pause or slower titration schedule often resolves the issue without sacrificing weight loss progress

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