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Two possible mechanisms of NO-mediated protein S-glutathionylation can be envisioned: through a GSNO (activated thiol) formation and its consequent reaction with protein-thiol (179) or through an intermediate protein-thiol nitrosylation (activated protein-thiol: analog of sulfenic acid) and its consequent reaction with GSH

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Corresponding AUC values (AUC(0-)) were measured at 4.38, 9.75, 13.59, and 18.22 g h/mL, while elimination half-lives (t1/2) were recorded as 2.14, 2.59, 2.62, and 2.69 h

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It has been licensed for aiding weight loss in non-diabetic people under the trade name Wegovy, strictly indicated for patients with obesity or overweight with diagnosed weight-related comorbidities [6, 7]

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