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This observation suggests that DET1 interacts with both COP1 and Ube2e proteins, facilitating the presentation of Ube2e proteins by DET1 claw to the COP1 RING dimer

Animal models: Nanoliposome-encapsulated GHK-Cu showed accelerated hair growth in C57BL/6 mice with visibly earlier anagen onset compared to free peptide controls (Tian et al., 2022)

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VMAT2 exploits this H gradient via protonmonoamine exchange to actively transport cytosolic monoamines into the vesicle against their concentration gradient, enabling vesicular storage and subsequent regulated neurotransmitter release