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Analysis confirmed they carried rare mutations of VKORC1, g

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The authors concluded that the inflammatory responses, oxidative stress, and imbalance of vasoactive substances caused by IH should be related to the frequency and degree of hypoxia

Wang JF, Milosveski V, Schramek C, Fong GH, Becks GP, Hill DJ

10.1074/jbc.M112.393140 5 BengaGh

Notably, bi-allelic MC4R mutation carriers had long-term outcomes as poor as those with bi-allelic LEPR or POMC mutations, suggesting that biallelic mutations in LMP genes generally lead to more severe impairment of surgical efficacy compared to heterozygous mutations