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they can be thrombogenic (provoke clot formation), so they are generally avoided in patients at risk for thrombotic events

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N Engl J Med 1999

It depends on your goals, health history, and how much you want to lose

Curr Pharm Des 9(30):24992511

Though each compound acts through distinct biochemical pathways, their overlapping molecular targets reveal an integrative network capable of restoring insulin signaling, modulating steroidogenesis, and re-establishing ovulatory rhythm, reflecting a multidimensional redox-endocrine homeostasis that current pharmacotherapies only partially address