soul trial oral semaglutide cardiovascular outcomes results 2025 nejm and in Patients with Type 2 Diabetes Oral Semaglutide and Cardiovascular Outcomes

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Unlike purely dietary approaches that often lead to yo-yo weight patterns, GLP-1 therapy provides sustained results

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GLP-1 receptor agonists work by: Stimulating insulin secretion from pancreatic beta cells in a glucose-dependent manner, which helps regulate blood sugar levels Slowing gastric emptying , meaning food remains in the stomach longer, promoting feelings of fullness Acting on appetite centres in the brain , particularly the hypothalamus, to reduce hunger signals and food cravings Decreasing glucagon secretion , which helps prevent excessive glucose production by the liver Most GLP-1 agonists are administered via subcutaneous injection, typically once weekly or once daily depending on the specific formulation, though oral semaglutide (Rybelsus) is also available

Chen et al., Smart H2S-triggered/therapeutic system (SHTS)-based nanomedicine

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