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In eye diseases like DR, high blood glucose and oxidative stress activate the Notch1-Hes signaling pathway, leading to ECM imbalance and promoting vascular dysfunction, inflammation, and retinal damage ( 2.5 Anti-angiogenic effect Abnormal angiogenesis plays a significant role in the pathogenesis of several eye diseases, particularly those involving retinal ischemia and neovascularization

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This infographic provides a structured, high-yield overview aligned with clinical and academic frameworks, covering: Core pharmacology and mechanism of action Key pharmacological effects on glucose homeostasis and appetite regulation Evidence-based therapeutic indications (Type 2 Diabetes & Obesity) Safety profile including side effects, toxicity risks, and contraindications Pharmacokinetics: metabolism, half-life, and excretion pathways Drug-drug interaction considerations for clinical optimization Overview of globally recognized brands such as semaglutide, liraglutide, dulaglutide, and tirzepatide formulations From enhancing insulin secretion to delaying gastric emptying, GLP-1 analogs are redefining patient-centric outcomes with a strong efficacy-safety balance